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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2016013Generated: October 29, 2026

1,4-Dimethyl-1H-1,2,3-triazole → 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2016013

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dimethyl-1H-1,2,3-triazoleHCID 15257142—
Reactant2-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-5-bromo-8-chloro-7-iodo-3,4-dihydroisoquinolin-1(2H)-oneHCID 118571992—
ReagentCesium pivalateHCID 583616—
CatalystBis([1,3-bis[2,6-di(propan-2-yl)phenyl]imidazol-2-ylidene]palladium);bis(2,3-dihydronaphthalene-1,4-dione)HCID 168430665—
SolventDimethylacetamideHCID 31374—
Product2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-oneHCID 86723831—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature90 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-b661b9b1f7f244fe8d7d1cfa672dc926
Source note39k HTE dataset from Pfizer