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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2016701Generated: October 30, 2026

(R)-ethyl 1-[5-(4-iodo-1-methyl-1H-pyrazol-5-yl)-2H-tetrazol-2-yl]ethyl carbonate → tert-butyl (3R)-3-[[4-[5-[2-[(1R)-1-ethoxycarbonyloxyethyl]tetrazol-5-yl]-1-methylpyrazol-4-yl]benzoyl]-(3-methyl-2-pyridinyl)amino]piperidine-1-carboxylate

https://huagongshe.com/reaction/2016701

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-ethyl 1-[5-(4-iodo-1-methyl-1H-pyrazol-5-yl)-2H-tetrazol-2-yl]ethyl carbonateHCID 117661191—
ReactantTert-butyl (R)-3-(N-(3-methylpyridin-2-YL)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)benzamido)piperidine-1-carboxylateHCID 123439813—
ReagentWaterHCID 962—
ReagentCesium fluorideHCID 25953—
CatalystTetrakis(triphenylphosphine)palladiumHCID 11979704—
SolventTolueneHCID 1140—
Producttert-butyl (3R)-3-[[4-[5-[2-[(1R)-1-ethoxycarbonyloxyethyl]tetrazol-5-yl]-1-methylpyrazol-4-yl]benzoyl]-(3-methyl-2-pyridinyl)amino]piperidine-1-carboxylateHCID 117661199—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature70 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-c1f14dff89f645528a32cd1710477711
Source note39k HTE dataset from Pfizer