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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2017286Generated: October 30, 2026

1H-Pyrazole, 4-bromo-1-methyl- → 2-(Pyridin-3-ylmethyl)quinoxaline

https://huagongshe.com/reaction/2017286

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Pyrazole, 4-bromo-1-methyl-HCID 167433—
ReactantHCID 178492748HCID 178492748—
ReagentPotassium BicarbonateHCID 516893—
ReagentPotassium t-amylateHCID 23683543—
CatalystDi-tert-butylmethylphosphineHCID 4190634—
CatalystHCID 178455864HCID 178455864—
Solvent1,4-DioxaneHCID 31275—
Product2-(Pyridin-3-ylmethyl)quinoxalineHCID 162265852—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature130 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-ddd9b62b283a4ff6bb3dea7d86b2f52b
Source note39k HTE dataset from Pfizer