3,5-Difluoromandelic acid → 2-[2-(3,5-Difluoro-phenyl)-2-hydroxy-acetylamino]-pentanoic acid [1-(1,1-dimethyl-2-morpholin-4-yl-ethyl)-1H-imidazol-4-yl]-amide

HRID 201794Notes

Reaction equation

HRID 201794 reaction equation
[CH3:1][C:2]([CH2:3][N:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1)([CH3:10])[n:11]1[cH:12][n:13][c:14]([NH:16][C:17]([CH:18]([CH2:19][CH2:20][CH3:21])[NH2:22])=[O:23])[cH:15]1.[F:24][c:25]1[cH:26][c:27]([CH:32]([C:33](=[O:34])[OH:35])[OH:36])[cH:28][c:29]([F:31])[cH:30]1>>[CH3:1][C:2]([CH2:3][N:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1)([CH3:10])[n:11]1[cH:12][n:13][c:14]([NH:16][C:17]([CH:18]([CH2:19][CH2:20][CH3:21])[NH:22][C:33]([CH:32]([c:27]2[cH:26][c:25]([F:24])[cH:30][c:29]([F:31])[cH:28]2)[OH:36])=[O:34])=[O:23])[cH:15]1

Participants

3

Reactant 2

HCID 5886483,5-Difluoromandelic acidHCID 671643342-Amino-pentanoic acid [1-(1,1-dimethyl-2-morpholin-4-yl-ethyl)-1H-imidazol-4-yl]-amide

Product 1

HCID 115840702-[2-(3,5-Difluoro-phenyl)-2-hydroxy-acetylamino]-pentanoic acid [1-(1,1-dimethyl-2-morpholin-4-yl-ethyl)-1H-imidazol-4-yl]-amide

Sources & evidence

ORD record
ord-fcaedc6b978049428cdba71343ec4627
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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