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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2018007Generated: October 29, 2026

tert-butyl (3R)-3-aminopiperidine-1-carboxylate → (R)-tert-butyl 3-((3-chloropyridin-2-yl)amino)piperidine-1-carboxylate

https://huagongshe.com/reaction/2018007

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl (3R)-3-aminopiperidine-1-carboxylateHCID 1501974—
Reactant3-Aminothiophene-2-carbohydrazideHCID 2807705—
Reactant2-Bromo-3-chloropyridineHCID 7016326—
ReagentCesium carbonateHCID 10796—
SolventTolueneHCID 1140—
Product(R)-tert-butyl 3-((3-chloropyridin-2-yl)amino)piperidine-1-carboxylateHCID 117652951—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-b1d137e859ce4a20a5c83e42b6256094
Source note39k HTE dataset from Pfizer