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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2018046Generated: October 26, 2026

3-Bromopyrazolo(1,5-a)pyrimidine → (R)-tert-butyl 3-(N-(3-methylpyridin-2-yl)-4-(pyrazolo[1,5-a]pyrimidin-3-yl)benzamido)piperidine-1-carboxylate

https://huagongshe.com/reaction/2018046

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromopyrazolo(1,5-a)pyrimidineHCID 12203208—
ReactantTert-butyl (R)-3-(N-(3-methylpyridin-2-YL)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)benzamido)piperidine-1-carboxylateHCID 123439813—
ReagentWaterHCID 962—
ReagentSodium HydroxideHCID 14798—
CatalystBenzimidazoleHCID 5798—
Catalyst2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 11155794—
SolventMethanolHCID 887—
Product(R)-tert-butyl 3-(N-(3-methylpyridin-2-yl)-4-(pyrazolo[1,5-a]pyrimidin-3-yl)benzamido)piperidine-1-carboxylateHCID 117652897—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-5c0362ce0d7e480dae4e6043fd97eabf
Source note39k HTE dataset from Pfizer