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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2018583Generated: October 29, 2026

HCID 67465643, compound → {[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2018583

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 67465643HCID 67465643—
ReactantHCID 178425084HCID 178425084—
ReagentCesium fluorideHCID 25953—
CatalystTetrakis(triphenylphosphine)palladiumHCID 11979704—
SolventTolueneHCID 1140—
Product{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-oneHCID 86723731—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature90 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-5819f8b530244444a4709be7c9d03cd1
Source note39k HTE dataset from Pfizer