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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2018771Generated: October 29, 2026

tert-Butyl (3R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate → tert-butyl 3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]pyrrolidine-1-carboxylate

https://huagongshe.com/reaction/2018771

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl (3R)-3-(hydroxymethyl)pyrrolidine-1-carboxylateHCID 1514340—
Reactant4,5-dichloro-N-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amineHCID 86679647—
ReagentHexaneHCID 8058—
Reagent2-Propanol, 2-methyl-, lithium salt (1:1)HCID 23664764—
Solvent1,4-DioxaneHCID 31275—
Producttert-butyl 3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]pyrrolidine-1-carboxylateHCID 123377533—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-04f93012a37d45a3ac3e7552992d12fa
Source note39k HTE dataset from Pfizer