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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2018798Generated: October 29, 2026

Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate → Tert-butyl 4-{[(4-aminopyrimidin-5-yl)oxy]methyl}piperidine-1-carboxylate

https://huagongshe.com/reaction/2018798

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 2764081—
Reactant5-Iodopyrimidin-4-amineHCID 13261510—
ReagentCesium carbonateHCID 10796—
Solvent2-Methyl-2-butanolHCID 6405—
ProductTert-butyl 4-{[(4-aminopyrimidin-5-yl)oxy]methyl}piperidine-1-carboxylateHCID 121409088—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-9d0090fb02fd484294ca2ad2842bc244
Source note39k HTE dataset from Pfizer