HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic Acid → Alpha-Hydroxyhippuric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic Acid | HCID 760 | — |
| Reactant | Benzamide | HCID 2331 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Alpha-Hydroxyhippuric acid | HCID 450272 | — |
Reaction Steps
A mixture of commercially available benzamide 35 and glyoxylic acid 41 was heated at reflux in acetone to give pure N-benzoyl-2-hydroxyglycine 65 as a colourless solid in quantitative yield (Scheme 4.12). The 1H n.m.r. spectrum supported formation of the ox-hydroxyglycine derivative 65 with the appearance of a methine (H2) doublet and broad amide (NH) doublet at δ 5.60 and δ 9.26 respectively. Spectroscopic data were in agreement with those reported in the literature.209
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745573B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-9b741076ad9544a8b379ce92eb9f70b0 |
| Source note | uspto-grants-2010_06 |