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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2018800Generated: October 31, 2026

Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate → Tert-butyl 4-{[(4-aminopyrimidin-5-yl)oxy]methyl}piperidine-1-carboxylate

https://huagongshe.com/reaction/2018800

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 2764081—
Reactant4-Amino-5-bromopyrimidineHCID 10261576—
ReagentPotassium Phosphate, TribasicHCID 62657—
CatalystPyrrole-2-Carboxylic AcidHCID 12473—
CatalystCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
SolventDimethylacetamideHCID 31374—
ProductTert-butyl 4-{[(4-aminopyrimidin-5-yl)oxy]methyl}piperidine-1-carboxylateHCID 121409088—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-736028f8bae945b19f093e0244125669
Source note39k HTE dataset from Pfizer