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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2018803Generated: October 29, 2026

Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate → Tert-butyl 4-{[(4-aminopyrimidin-5-yl)oxy]methyl}piperidine-1-carboxylate

https://huagongshe.com/reaction/2018803

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 2764081—
Reactant5-Iodopyrimidin-4-amineHCID 13261510—
ReagentPotassium t-amylateHCID 23683543—
CatalystDichloro(1,10-phenanthroline)copper(II)HCID 6100472—
SolventDimethylacetamideHCID 31374—
ProductTert-butyl 4-{[(4-aminopyrimidin-5-yl)oxy]methyl}piperidine-1-carboxylateHCID 121409088—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-d70e22486df744148fe904fbfc7bb3a1
Source note39k HTE dataset from Pfizer