Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2018897Generated: October 30, 2026

2-Bromophenetole → tert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylate

https://huagongshe.com/reaction/2018897

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-BromophenetoleHCID 68500—
Reactant(R)-1-Boc-3-hydroxypiperidineHCID 1514398—
ReagentPotassium t-amylateHCID 23683543—
Catalystpalladium(II) acetateHCID 167845—
CatalystBrettphosHCID 25112535—
Solvent2-Methyl-2-butanolHCID 6405—
Producttert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylateHCID 131737068—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-fc9792009f8d42208403e7d28d33ac67
Source note39k HTE dataset from Pfizer