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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2019133Generated: October 30, 2026

Benzene, 1-ethoxy-2-iodo- → tert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylate

https://huagongshe.com/reaction/2019133

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, 1-ethoxy-2-iodo-HCID 136415—
Reactant(R)-1-Boc-3-hydroxypiperidineHCID 1514398—
ReagentCesium carbonateHCID 10796—
Catalystpalladium(II) acetateHCID 167845—
CatalystBippyPhosHCID 11547931—
SolventTolueneHCID 1140—
Producttert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylateHCID 131737068—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-8b23b38dc3494e0bb877038dbb86a221
Source note39k HTE dataset from Pfizer