Ammonia → HCID 86752274, compound

HRID 2020Notes

Reaction equation

HRID 2020 reaction equation
[CH2:1]([O:3][CH2:4][N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][P:19](=[O:31])([O-:30])[O:20]CCCC3C=CC=CC=3)[C:10](=[O:32])[N:9]([CH3:33])[C:8]=2[N:7]=[CH:6]1)[CH3:2].N>C(O)C.[Pd]>[CH2:1]([O:3][CH2:4][N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][P:19](=[O:20])([O-:31])[O-:30])[C:10](=[O:32])[N:9]([CH3:33])[C:8]=2[N:7]=[CH:6]1)[CH3:2].[CH2:13]([NH3+:5])[CH3:8].[CH2:13]([NH3+:5])[CH3:8]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 86752275HCID 86752275, compound

Product 1

HCID 86752274HCID 86752274, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6.3 g (0.013 mol) of benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate were hydrogenated in 100 ml of ethanol over 0.5 g of palladium (10%) on active carbon at room temperature in the course of 4 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, the solution obtained was treated with methanolic ammonia and the residue which remained after evaporating the solvent was then crystallized from diisopropyl ether.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe solution obtained
  4. customafter evaporating the solvent
  5. customwas then crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-ed0a8010fe1240b0b02babed64992c40
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

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