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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2020176Generated: October 29, 2026

Methyl Acrylate → (E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylate

https://huagongshe.com/reaction/2020176

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl AcrylateHCID 7294—
Reactant4-Bromo-2,6-difluorobenzaldehydeHCID 2773290—
ReagentDiisopropylethylamineHCID 81531—
ReagentLithium ChlorideHCID 433294—
CatalystTricyclohexylphosphineHCID 75806—
Catalystpalladium(II) acetateHCID 167845—
SolventAcetonitrileHCID 6342—
Product(E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylateHCID 117719453—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-0c481d6bd13f4c8ba8d05d87607fba50
Source note39k HTE dataset from Pfizer