Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2020306Generated: October 29, 2026

Methyl Acrylate → (E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylate

https://huagongshe.com/reaction/2020306

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl AcrylateHCID 7294—
Reactant4-Bromo-2,6-difluorobenzaldehydeHCID 2773290—
ReagentMonobasic potassium phosphateHCID 516951—
CatalystTri-o-tolylphosphineHCID 80271—
Catalystpalladium(II) acetateHCID 167845—
SolventDimethylacetamideHCID 31374—
Product(E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylateHCID 117719453—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-2a6f69f5edae45c8bd1a87f1b9555112
Source note39k HTE dataset from Pfizer