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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2020476Generated: October 29, 2026

1,4-Dimethyl-1H-1,2,3-triazole → 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2020476

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dimethyl-1H-1,2,3-triazoleHCID 15257142—
Reactant2-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-5-bromo-8-chloro-7-iodo-3,4-dihydroisoquinolin-1(2H)-oneHCID 118571992—
ReagentWaterHCID 962—
ReagentPotassium phosphate, tribasic, monohydrateHCID 22031701—
Catalystpalladium(II) acetateHCID 167845—
Catalyst1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 636044—
Solvent2-Methyl-2-butanolHCID 6405—
Product2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-oneHCID 86723831—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-7981e3fa496b442590f7fa04a1116d18
Source note39k HTE dataset from Pfizer