Dichloromethane → 1-O-tert-butyl 2-O-[3-[2-[1-[2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidine-2-carbonyl]oxyacetyl]-8-oxo-5,9,10,11-tetrahydronaphtho[3,2-c]isochromen-9-yl] 4-methylpyrrolidine-1,2-dicarboxylate

HRID 202085Notes

Reaction equation

HRID 202085 reaction equation
[C:44]([CH3:45])([CH3:46])([CH3:47])[O:48][C:49](=[O:50])[N:51]1[CH:52]([C:57](=[O:58])[OH:59])[CH2:53][CH:54]([CH3:56])[CH2:55]1.[C:60](=[O:61])([O-:62])[O-:63].[CH3:1][O:2][C:3](=[O:4])[NH:5][CH:6]([C:7](=[O:8])[N:9]1[CH:10]([C:15](=[O:16])[O:17][CH2:18][C:19](=[O:20])[c:21]2[cH:22][cH:23][c:24]3[c:25]([cH:40]2)[CH2:26][O:27][c:28]2[cH:29][c:30]4[c:31]([cH:32][c:33]2-3)[CH2:34][CH2:35][CH:36]([Br:39])[C:37]4=[O:38])[CH2:11][CH2:12][CH:13]1[CH3:14])[CH:41]([CH3:42])[CH3:43].[Cl:66][CH2:67][Cl:68].[Cs+:64].[Cs+:65]>>[CH3:1][O:2][C:3](=[O:4])[NH:5][CH:6]([C:7](=[O:8])[N:9]1[CH:10]([C:15](=[O:16])[O:17][CH2:18][C:19](=[O:20])[c:21]2[cH:22][cH:23][c:24]3[c:25]([cH:40]2)[CH2:26][O:27][c:28]2[cH:29][c:30]4[c:31]([cH:32][c:33]2-3)[CH2:34][CH2:35][CH:36]([O:59][C:57]([CH:52]2[N:51]([C:49]([O:48][C:44]([CH3:45])([CH3:46])[CH3:47])=[O:50])[CH2:55][CH:54]([CH3:56])[CH2:53]2)=[O:58])[C:37]4=[O:38])[CH2:11][CH2:12][CH:13]1[CH3:14])[CH:41]([CH3:42])[CH3:43]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 212513481-(Tert-butoxycarbonyl)-4-methylpyrrolidine-2-carboxylic acidHCID 123200125[2-(9-Bromo-8-oxo-5,9,10,11-tetrahydronaphtho[2,3-c]isochromen-3-yl)-2-oxoethyl] 1-[2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidine-2-carboxylate

Product 1

HCID 1233229331-O-tert-butyl 2-O-[3-[2-[1-[2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidine-2-carbonyl]oxyacetyl]-8-oxo-5,9,10,11-tetrahydronaphtho[3,2-c]isochromen-9-yl] 4-methylpyrrolidine-1,2-dicarboxylate

Sources & evidence

ORD record
ord-402cd553c9b146a1928ae4f9975e1809
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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