Benzyl 4-(3-oxo-4-morpholinyl)piperidin-1-carboxylate → HCID 53255666, compound

HRID 20218Notes

Reaction equation

HRID 20218 reaction equation
[O:1]=[C:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[CH:8]1[CH2:13][CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[CH2:10][CH2:9]1>C(O)C.[Pd]>[NH:11]1[CH2:12][CH2:13][CH:8]([N:3]2[CH2:4][CH2:5][O:6][CH2:7][C:2]2=[O:1])[CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 46223102Benzyl 4-(3-oxo-4-morpholinyl)piperidin-1-carboxylate

Product 1

HCID 53255666HCID 53255666, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Benzyl 4-(3-oxo-4-morpholinyl)piperidin-1-carboxylate (3.8 g) obtained in Example 7b) was dissolved in ethanol (50 mL), 10% palladium on carbon (containing 50% water; 0.38 g) was added thereto, and the mixture was stirred at room temperature for 15 hours under a hydrogen atmosphere. The reaction mixture was filtered and the solvent was distilled off under reduced pressure to obtain the title compound (2.2 g, quantitative) as a light yellow oil.

Workup

  1. filtrationThe reaction mixture was filtered
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-30695a05108f4b01b9139dbf8f7d6d04
Source dataset
uspto-grants-2010_06
Patent number
US07745623B2

Reaction notes

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