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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2023621Generated: October 30, 2026

2-Cyclohexen-1-one, 4-methyl-, (R)- → Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

https://huagongshe.com/reaction/2023621

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Cyclohexen-1-one, 4-methyl-, (R)-HCID 11105334—
ReactantHCID 178427897HCID 178427897—
ReagentPhosphazene base P2-t-Bu solutionHCID 4275357—
CatalystHCID 178420231HCID 178420231—
SolventWaterHCID 962—
Solvent1,4-DioxaneHCID 31275—
ProductTert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylateHCID 139388538—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature40 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-77d12d71fc7d45199bbc271ef5bb7916
Source note39k HTE dataset from Pfizer