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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2023647Generated: November 2, 2026

2-Cyclohexen-1-one, 4-methyl-, (R)- → Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

https://huagongshe.com/reaction/2023647

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Cyclohexen-1-one, 4-methyl-, (R)-HCID 11105334—
ReactantHCID 178427897HCID 178427897—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
CatalystHCID 178420231HCID 178420231—
SolventWaterHCID 962—
Solvent1,4-DioxaneHCID 31275—
ProductTert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylateHCID 139388538—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature40 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-af6e9f1810f84c66b418786cefc5bfda
Source note39k HTE dataset from Pfizer