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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2023735Generated: October 30, 2026

Ethylene → 8-chloro-5-methyl-3,4-dihydroisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2023735

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyleneHCID 6325—
ReactantHCID 178476725HCID 178476725—
ReagentSodium BicarbonateHCID 516892—
Catalystdichloro(pentamethylcyclopentadienyl)rhodium (III) dimerHCID 74890113—
SolventAcetonitrileHCID 6342—
Product8-chloro-5-methyl-3,4-dihydroisoquinolin-1(2H)-oneHCID 118572062—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-a3e36d1d20db441ba203f39d7f4df99f
Source note39k HTE dataset from Pfizer