Methanol → racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-2'-(2,6-dimethylphenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 202374Notes

Reaction equation

HRID 202374 reaction equation
[CH2:1]([O:2][C:3](=[O:4])[N:6]1[C:7](=[O:37])[C:8]2([c:9]3[cH:10][cH:11][c:12]([Cl:15])[cH:13][c:14]31)[CH:16]([c:29]1[c:30]([CH3:36])[cH:31][cH:32][cH:33][c:34]1[CH3:35])[NH:17][C:18](=[O:28])[CH2:19][CH:20]2[c:21]1[cH:22][c:23]([Cl:27])[cH:24][cH:25][cH:26]1)[CH3:5].[CH3:40][OH:41].[Na+:39].[OH-:38]>>[NH:6]1[C:7](=[O:37])[C:8]2([c:9]3[cH:10][cH:11][c:12]([Cl:15])[cH:13][c:14]31)[CH:16]([c:29]1[c:30]([CH3:36])[cH:31][cH:32][cH:33][c:34]1[CH3:35])[NH:17][C:18](=[O:28])[CH2:19][CH:20]2[c:21]1[cH:22][c:23]([Cl:27])[cH:24][cH:25][cH:26]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 76568054racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-2'-(2,6-dimethylphenyl)-2,3-dihydro-2,6'-dioxo spiro[indole-3,3'-piperidine]-1-carboxylic acid ethyl ester

Product 1

HCID 74371669racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-2'-(2,6-dimethylphenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record
ord-938f56e1af00414899bddf4e119ee567
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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