HCID 68420297, compound → 1-Piperidin-4-yl-dihydropyrimidin-2,4(1H,3H)-dione

Participants

Reaction Steps

A solution of benzyl 4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)piperidin-1-carboxylate (0.18 g) obtained in Example 45d) and 20% palladium on carbon (containing 60% water, 36 mg) in DMF (10 mL) was stirred at room temperature for 3 hours under a hydrogen atmosphere, and the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to obtain the title compound (0.11 g,, quantitative) as a white powder.

Provenance & Evidence