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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2024407Generated: November 1, 2026

HCID 178422847, compound → Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

https://huagongshe.com/reaction/2024407

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 178422847HCID 178422847—
ReactantHCID 178452263HCID 178452263—
ReagentLithium magnesium 2,2,6,6-tetramethylpiperidin-1-ide dichlorideHCID 25150783—
CatalystBinap, (A+-)-HCID 634876—
CatalystHCID 178443481HCID 178443481—
ProductTert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylateHCID 139388538—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-a9ca46b7df3344deaf2ec0877ff8b872
Source note39k HTE dataset from Pfizer