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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2024727Generated: October 26, 2026

Acetylene → 4-Chloro-1,7-naphthyridin-8(7H)-one

https://huagongshe.com/reaction/2024727

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetyleneHCID 6326—
Reactant4-chloro-N-methoxypyridine-2-carboxamideHCID 102285909—
ReagentPotassium AcetateHCID 517044—
ReagentSilver hexafluoroantimonateHCID 16687962—
Catalystdichloro(pentamethylcyclopentadienyl)rhodium (III) dimerHCID 74890113—
SolventIsopropyl AcetateHCID 7915—
Product4-Chloro-1,7-naphthyridin-8(7H)-oneHCID 133625243—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-6e9cbd50c69e44ecb2bfe3681ddb11a7
Source note39k HTE dataset from Pfizer