3-Methyl-7-propylpurine-2,6-dione → Diethyl [4-(3-methyl-7-propyl-xanthin-1-yl)butyl]phosphonate

HRID 2025Notes

Reaction equation

HRID 2025 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][CH2:12][CH3:13])[C:6]=2[C:5](=[O:14])[NH:4][C:3]1=[O:15].Cl[CH2:17][CH2:18][CH2:19][CH2:20][P:21]([O:26][CH2:27][CH3:28])(=[O:25])[O:22][CH2:23][CH3:24]>>[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][CH2:12][CH3:13])[C:6]=2[C:5](=[O:14])[N:4]([CH2:17][CH2:18][CH2:19][CH2:20][P:21](=[O:25])([O:26][CH2:27][CH3:28])[O:22][CH2:23][CH3:24])[C:3]1=[O:15]

Participants

3

Reactant 2

HCID 33143973-Methyl-7-propylpurine-2,6-dioneHCID 19689195Diethyl(4-chlorobutyl)phosphonate

Product 1

HCID 22446293Diethyl [4-(3-methyl-7-propyl-xanthin-1-yl)butyl]phosphonate

Procedure

The title substance was prepared from 0.072 mol of 3-methyl-7-propyl-xanthine and 0.072 mol of diethyl 4-chlorobutanephosphonate analogously to Example 23, chromatographed on silica gel (eluent: dichloromethane/methanol 20:1) and crystallized from diisopropyl ether.

Workup

  1. customchromatographed on silica gel (eluent: dichloromethane/methanol 20:1)
  2. customcrystallized from diisopropyl ether

Sources & evidence

ORD record
ord-82da64e54168413bb57aba668109b96d
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

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