Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2025486Generated: October 30, 2026

N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamide → N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

https://huagongshe.com/reaction/2025486

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamideHCID 45480190—
Reactant4,6-dichloro-1-[(2R)-oxan-2-yl]pyrazolo[4,3-c]pyridineHCID 125482419—
ReagentSodium AcetateHCID 517045—
Solvent2-Methyl-2-butanolHCID 6405—
ProductN-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamideHCID 118512378—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-48b1c5fd4cbc4997a5d2d288b84ea081
Source note39k HTE dataset from Pfizer