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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2025540Generated: October 30, 2026

N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamide → N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

https://huagongshe.com/reaction/2025540

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamideHCID 45480190—
Reactant4,6-dichloro-1-[(2R)-oxan-2-yl]pyrazolo[4,3-c]pyridineHCID 125482419—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
SolventDimethylformamideHCID 6228—
ProductN-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamideHCID 118512378—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-c0eb7f9fcb694b7d95324f9258e54c4a
Source note39k HTE dataset from Pfizer