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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2025792Generated: November 1, 2026

N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamide → N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

https://huagongshe.com/reaction/2025792

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamideHCID 45480190—
Reactant4,6-dichloro-1-[(2R)-oxan-2-yl]pyrazolo[4,3-c]pyridineHCID 125482419—
Reagent4-(Dimethylamino)pyridineHCID 14284—
SolventTolueneHCID 1140—
ProductN-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamideHCID 118512378—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-1fa9fb79fe5b48219f6b11ae5e62de2c
Source note39k HTE dataset from Pfizer