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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2025819Generated: November 1, 2026

N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamide → N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

https://huagongshe.com/reaction/2025819

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamideHCID 45480190—
Reactant4,6-dichloro-1-[(2R)-oxan-2-yl]pyrazolo[4,3-c]pyridineHCID 125482419—
Reagent2,6-Di-tert-butyl-4-methylpyridineHCID 98898—
SolventDimethylformamideHCID 6228—
ProductN-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamideHCID 118512378—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-4178e95f7bb442daa4e6589efa46e2d7
Source note39k HTE dataset from Pfizer