Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2025935Generated: October 30, 2026

N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamide → N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

https://huagongshe.com/reaction/2025935

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamideHCID 45480190—
Reactant4,6-dichloro-1-[(2R)-oxan-2-yl]pyrazolo[4,3-c]pyridineHCID 125482419—
Reagent2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineHCID 3513851—
SolventTetrahydrofuranHCID 8028—
ProductN-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamideHCID 118512378—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-8340db25b02a4d64a765136c5f71fee7
Source note39k HTE dataset from Pfizer