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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2026427Generated: November 1, 2026

Tetrabutylammonium Cyanide → 4-Bromo-5-fluoro-2-methylbenzaldehyde

https://huagongshe.com/reaction/2026427

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrabutylammonium CyanideHCID 165872—
Reactant4-Bromo-5-fluoro-2-methylbenzaldehydeHCID 12187217—
CatalystTricyclohexylphosphineHCID 75806—
Catalystpalladium(II) acetateHCID 167845—
Solvent1,4-DioxaneHCID 31275—
Product4-Bromo-5-fluoro-2-methylbenzaldehydeHCID 12187217—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-345a4218b2ed498a821080fd1ef2fe1a
Source note39k HTE dataset from Pfizer