4-Chlorophenyl isothiocyanate → Ethyl 1-{[(4-chlorophenyl)amino]thioxomethyl}piperidine-4-carboxylate

Participants

Reaction Steps

A mixture of 4-chlorophenyl isothiocyanate (3.5 g, 20.7 mmol), and ethyl isonipecotate (3.19 mL, 20.7 mmol) in dichloromethane (30 mL) was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure, the residue was triturated with ether and the resulting solid was filtered off and dried to afford the title compound as a white solid, 6.27 g.

Provenance & Evidence