反应详情

4-Nitro-1H-pyrazole-3-carboxylic acid (4-fluorophenyl)-amide (15 g) was dissolved in 200 ml of ethanol, treated with 1.5 g of 10% palladium on carbon under a nitrogen atmosphere, then hydrogenated at room temperature and pressure overnight. The catalyst was removed by filtration through Celite and the filtrate evaporated. The crude product was dissolved in acetone/water (100 ml:100 ml) and after slow evaporation of the acetone the product was collected by filtration as a brown crystalline solid (8.1 g). (LC/MS: Rt 1.58, [M+H]+ 220.95).

1. customhydrogenated at room temperature
2. custompressure overnight
3. customThe catalyst was removed by filtration through Celite
4. customthe filtrate evaporated
5. dissolutionThe crude product was dissolved in acetone/water (100 ml:100 ml)
6. customafter slow evaporation of the acetone the product
7. filtrationwas collected by filtration as a brown crystalline solid (8.1 g)