Dichloromethane → 4-Chloro-5-(4-(chloromethyl)-2-fluorobenzyl)-6-methylpyrimidin-2-amine

HRID 202880Notes

Reaction equation

HRID 202880 reaction equation
[Cl:24][CH2:25][Cl:26].[NH2:5][c:6]1[n:7][c:8]([CH3:23])[c:9]([CH2:13][c:14]2[c:15]([F:22])[cH:16][c:17]([CH2:20][OH:21])[cH:18][cH:19]2)[c:10]([Cl:12])[n:11]1.[S:1]([Cl:2])([Cl:3])=[O:4]>>[Cl:3][CH2:20][c:17]1[cH:16][c:15]([F:22])[c:14]([CH2:13][c:9]2[c:8]([CH3:23])[n:7][c:6]([NH2:5])[n:11][c:10]2[Cl:12])[cH:19][cH:18]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 86633403(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)methanol

Product 1

HCID 866334044-Chloro-5-(4-(chloromethyl)-2-fluorobenzyl)-6-methylpyrimidin-2-amine

Sources & evidence

ORD record
ord-ae57c747a72543beb5a7efd3f877c29f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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