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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2030973Generated: October 31, 2026

3,5-Dibromo-4-methylpyridine → 5-Bromo-4-methylpyridine-3-carbonitrile

https://huagongshe.com/reaction/2030973

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Dibromo-4-methylpyridineHCID 819338—
ReactantTetrabutylammonium HydroxideHCID 2723671—
Catalyst[1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichlormethaneHCID 75537289—
Solvent1,4-DioxaneHCID 31275—
Product5-Bromo-4-methylpyridine-3-carbonitrileHCID 7060681—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-9e1df6318aa144d7a0431e5ed8cdc1ee
Source note39k HTE dataset from Pfizer