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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2031045Generated: October 31, 2026

3,5-Dibromo-4-methylpyridine → 5-Bromo-4-methylpyridine-3-carbonitrile

https://huagongshe.com/reaction/2031045

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Dibromo-4-methylpyridineHCID 819338—
Reactantsodium bis(trimethylsilyl)azanideHCID 178504303—
Catalystpalladium(II) acetateHCID 167845—
CatalystHCID 178454858HCID 178454858—
SolventDimethyl SulfoxideHCID 679—
Product5-Bromo-4-methylpyridine-3-carbonitrileHCID 7060681—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-cd2abe13494b44d39c6a5dfd725397e5
Source note39k HTE dataset from Pfizer