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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2031440Generated: November 1, 2026

4-Bromo-2-methylpyridine → tert-Butyl 2-(2-methylpyridin-4-yl)pyrrolidine-1-carboxylate

https://huagongshe.com/reaction/2031440

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-methylpyridineHCID 2762835—
ReactantPotassium (1-((tert-butoxy)carbonyl)pyrrolidin-2-yl)trifluoroboranuideHCID 74787601—
ReagentCesium carbonateHCID 10796—
Catalyst2-(Pyridin-2-yl)quinoline-4-carboxylic acidHCID 24103—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
SolventDimethylformamideHCID 6228—
Producttert-Butyl 2-(2-methylpyridin-4-yl)pyrrolidine-1-carboxylateHCID 102543294—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-7f6056a872f64de09cef22310c8a45d5
Source note39k HTE dataset from Pfizer