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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2031465Generated: November 2, 2026

1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid → tert-Butyl 2-(2-methylpyridin-4-yl)pyrrolidine-1-carboxylate

https://huagongshe.com/reaction/2031465

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acidHCID 268472—
Reactant4-Bromo-2-methylpyridineHCID 2762835—
Reagent2,6-LutidineHCID 7937—
Catalyst2,2'-BiquinolineHCID 8412—
CatalystBis(1,5-cyclooctadiene) nickelHCID 3032389—
SolventAcetoneHCID 180—
SolventMethanolHCID 887—
Producttert-Butyl 2-(2-methylpyridin-4-yl)pyrrolidine-1-carboxylateHCID 102543294—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-9af46ede1c0e4f49b9d08da386f113d7
Source note39k HTE dataset from Pfizer