HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitromethane → 1-(3,5-Difluorophenyl)-2-nitroethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,5-Difluorobenzaldehyde | HCID 588160 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(3,5-Difluorophenyl)-2-nitroethanol | HCID 68562553 | — |
Reaction Steps
Add nitromethane (200 mL) to a suspension of potassium carbonate (30 g) and 3,5-difluorobenzaldehyde (200 g) in tetrahydrofuran (600 mL) at room temperature. Stir at room temperature overnight, filter, wash with ethyl acetate and concentrate to give the desired compound as a crude oil (330 g) which is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745438B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-2cf9865e0403426b8bcade080e174cea |
| Source note | uspto-grants-2010_06 |