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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2033449Generated: October 30, 2026

(Difluoromethyl)trimethylsilane → tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

https://huagongshe.com/reaction/2033449

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Difluoromethyl)trimethylsilaneHCID 11170968—
Reactanttert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132189892—
ReagentPotassium t-amylateHCID 23683543—
Catalyst(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladiumHCID 6505921—
CatalystBis(cyclopentyl(diphenyl)phosphane);ironHCID 24721398—
Solvent1,4-DioxaneHCID 31275—
Producttert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132190055—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-53c7e8c6d6944d1bbef17de2a68a7edb
Source note39k HTE dataset from Pfizer