HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2033458Generated: October 30, 2026
(Difluoromethyl)trimethylsilane → tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
https://huagongshe.com/reaction/2033458
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (Difluoromethyl)trimethylsilane | HCID 11170968 | — |
| Reactant | tert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate | HCID 132189892 | — |
| Reagent | 2-Propanol, 2-methyl-, lithium salt (1:1) | HCID 23664764 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | Bis(cyclopentyl(diphenyl)phosphane);iron | HCID 24721398 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate | HCID 132190055 | — |
| Internal standard | 9-Phenylanthracene | HCID 11766 | — |
Provenance & Evidence
| DOI | 10.1038/s41557 |
|---|
| Source dataset | 39k HTE dataset from Pfizer |
|---|
| ORD ID | ord-7470ab04dac34cf5adb6588908205fea |
|---|
| Source note | 39k HTE dataset from Pfizer |
|---|
