HRID20337

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](OCc1ccccc1)[C@H]1CO[C@H](OCCC(C)(C)C)CN1C(=O)OC(C)(C)C

HCID58972242

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1CO[C@@H](OCCC(C)(C)C)CN1C(=O)OC(C)(C)C

HCID68559571

未命名化合物

收率 99.4%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Stir (2S,5R)-5-[(1S,2S)-2-Acetylamino-1-benzyloxy-3-(3,5-difluorophenyl)-propyl]-2-(3,3-dimethylbutoxy)-morpholine-4-carboxylic acid tert-butyl ester (0.18 g, 0.29 mmol) and 10% palladium on carbon (0.18 g) in ethanol (5 mL) under hydrogen at room temperature for 14 hours. Filter through Celite® and concentrate to give the title compound (0.148 g, 99.4% yield).

WORKUP

后处理

filtrationFilter through Celite®
concentrationconcentrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-da9a87b8722e477f8f1243f4f570f7a3
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745438B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([O:29]CC2C=CC=CC=2)[C@@H:15]([NH:25][C:26](=[O:28])[CH3:27])[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:12][O:11][C@H:10]([O:37][CH2:38][CH2:39][C:40]([CH3:43])([CH3:42])[CH3:41])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([OH:29])[C@@H:15]([NH:25][C:26](=[O:28])[CH3:27])[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:12][O:11][C@@H:10]([O:37][CH2:38][CH2:39][C:40]([CH3:43])([CH3:42])[CH3:41])[CH2:9]1)=[O:7])([CH3:2])([CH3:4])[CH3:3]