Methyl 5-chloropyrazine-2-carboxylate → 5-{4-Chloro-3-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxy}-pyrazine-2-carboxylic acid methyl ester

HRID 203499Notes

Reaction equation

HRID 203499 reaction equation
[CH3:24][O:25][C:26](=[O:27])[c:28]1[n:29][cH:30][c:31]([Cl:34])[n:32][cH:33]1.[Cl:1][c:2]1[c:3]([CH:9]([C:10]([C:11]([F:12])([F:13])[F:14])([OH:15])[c:16]2[cH:17][c:18]([Cl:22])[n:19][cH:20][cH:21]2)[CH3:23])[cH:4][c:5]([OH:8])[cH:6][cH:7]1>>[Cl:1][c:2]1[c:3]([CH:9]([C:10]([C:11]([F:12])([F:13])[F:14])([OH:15])[c:16]2[cH:17][c:18]([Cl:22])[n:19][cH:20][cH:21]2)[CH3:23])[cH:4][c:5]([O:8][c:31]2[cH:30][n:29][c:28]([C:26]([O:25][CH3:24])=[O:27])[cH:33][n:32]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 406081Methyl 5-chloropyrazine-2-carboxylateHCID 252546034-Chloro-3-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol

Product 1

HCID 723105855-{4-Chloro-3-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxy}-pyrazine-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-fa7846af4c2d498aa3455f9c246f4c2a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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