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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2035111Generated: October 31, 2026

(Difluoromethyl)trimethylsilane → tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

https://huagongshe.com/reaction/2035111

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Difluoromethyl)trimethylsilaneHCID 11170968—
Reactanttert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132189892—
ReagentLithium HexamethyldisilazideHCID 2733832—
Catalystpalladium(II) acetateHCID 167845—
CatalystBippyPhosHCID 11547931—
Solvent2-Methyl-2-butanolHCID 6405—
Producttert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132190055—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-601e79f72abf4c1d83b3e4807319d79c
Source note39k HTE dataset from Pfizer