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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2035161Generated: October 31, 2026

(Difluoromethyl)trimethylsilane → tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

https://huagongshe.com/reaction/2035161

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Difluoromethyl)trimethylsilaneHCID 11170968—
Reactanttert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132189892—
ReagentLithium HexamethyldisilazideHCID 2733832—
CatalystHCID 178420029HCID 178420029—
Solvent2-Methyl-2-butanolHCID 6405—
Producttert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132190055—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-54d97cc01f954a8e9da27e1e2a8d0e3b
Source note39k HTE dataset from Pfizer