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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2035169Generated: November 1, 2026

(Difluoromethyl)trimethylsilane → tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

https://huagongshe.com/reaction/2035169

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Difluoromethyl)trimethylsilaneHCID 11170968—
Reactanttert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132189892—
ReagentLithium HexamethyldisilazideHCID 2733832—
Catalystpalladium(II) acetateHCID 167845—
Catalyst2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 11155794—
SolventTolueneHCID 1140—
Producttert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132190055—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-8891c42523184d76a370984e5d4b6a96
Source note39k HTE dataset from Pfizer