HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-Methoxy-4-(4-methoxybenzylsulfanyl)-piperidine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carboxylic acid | HCID 66793962 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Methoxy-4-(4-methoxybenzylsulfanyl)-piperidine-4-carbonyl chloride | HCID 86663300 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
700 mg 1-Methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carboxylic acid (from Step 5) was dissolved in 10 ml toluene, 1 drop N,N-dimethylformamide was added, followed by 400 mg thionyl chloride. The mixture was heated to 100° C. for 1 hour, at which time the evolution of gas has ceased. The solvent was evaporated, to yield crude 1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08574607B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6b07e230cd494fd79e052defdee85325 |
| Source note | uspto-grants-2013_11 |